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The International Journal of Lower Extremity Wounds
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Hyperhomocysteinemia and Venous Thrombosis

Paul Lee, PhD

Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

Kailash Prasad, MD, PhD

Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada, prasadk{at}sask.usask.ca

Deep vein thrombosis (DVT) leads to venous ulcers in later life. Venous ulcers are the majority of chronic lower extremity wounds. Recent evidence suggests that hyperhomocysteinemia is an independent risk factor for venous thrombosis. Other evidence suggests that dietary supplementation with folic acids and vitamins helps to change hyper-homocysteinemia. This may be the key to wound management in the future.

Key Words: hyperhomocysteinemia • venous thrombosis • folic acid • vitamin B12 • oxyradicals • coagulation

The International Journal of Lower Extremity Wounds, Vol. 1, No. 1, 4-12 (2002)
DOI: 10.1177/153473460200100102
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 INT J LOW EXTREM WOUNDSHome page
E. M. Schwartzfarb and P. Romanelli
Hyperhomocysteinemia and Lower Extremity Wounds
International Journal of Lower Extremity Wounds, September 1, 2008; 7(3): 126 - 136.
[Abstract] [PDF]