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The International Journal of Lower Extremity Wounds
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Models to Study Ischemia in Chronic Wounds

Michael Schäffer, MD

Department of Surgery, University of Tübingen, Germany, michael.schaeffer{at}med.uni-tuebingen.de

Maria Witte, MD

Department of Surgery, University of Tübingen, Germany

Horst-Dieter Becker, MD

Department of Surgery, University of Tübingen, Germany

Wound healing is a complex immune response designed to achieve tissue repair following injury. Imbalance of stimulating and inhibiting factors cause failure of healing. Ischemia is a major cause of wound repair dysregulation and may be limb and life threatening. Investigating ischemic wound healing using animal models minimizes the complex accompanying factors that are usually present in humans, such as age or diabetes. This paper presents a limited review on normal physiological healing and on models that are used to study compromised healing under ischemic conditions.

Key Words: wound healing • ischemia • animal • model

The International Journal of Lower Extremity Wounds, Vol. 1, No. 2, 104-111 (2002)
DOI: 10.1177/1534734602001002005
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