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The International Journal of Lower Extremity Wounds
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Dermal Changes in the Lower Leg Skin of Patients With Venous Hypertension

Sarah E. Herrick, BSc, PhD

School of Biological Sciences, University of Manchester, Manchester, UK and Department of Medicine, University College London, Rayne Institute, London, UK, sarah.herrick{at}man.ac.uk

Linda J. Treharne, MSc, MB, ChB, FRCS

School of Biological Sciences, University of Manchester, Manchester, UK and Department of Medicine, University College London, Rayne Institute, London, UK

Alex M. deGiorgio-Miller, BSc

School of Biological Sciences, University of Manchester, Manchester, UK and Department of Medicine, University College London, Rayne Institute, London, UK

Patients with chronic venous disease may develop characteristic changes in the skin of the lower limb known as lipodermatosclerosis (LDS). The affected skin becomes indurated and pigmented and often ulcerates. The degree of induration associated with LDS correlates directly with ulcer formation and leads to a subsequent delayed rate of healing. However, there is limited information regarding the cellular and molecular events that lead from venous dysfunction to LDS development. This article reviews the current knowledge of the clinical progression of chronic venous disease, summarizing the histological findings from these authors’ laboratory and other studies on LDS, and offers possible mechanisms to explain the fibrotic changes associated with this condition.

Key Words: lipodermatosclerosis • venous ulcers • fibrosis • fibrin • hemosiderin

The International Journal of Lower Extremity Wounds, Vol. 1, No. 2, 80-86 (2002)
DOI: 10.1177/1534734602001002002
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