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The International Journal of Lower Extremity Wounds
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A Clinical Investigation on the Characteristics and Outcomes of Treating Chronic Lower Extremity Wounds using the TissueTech Autograft System

L. Uccioli, MD

Cattedra di Endocrinologia Università di Roma Tor Vergata, Rome, Italy, luigi.uccioli{at}uniroma2.it

The application of tissue engineering technology to wound healing has resulted in the development of a number of "living skin equivalents." These have become a viable option in the treatment of chronic, nonhealing wounds. Such wounds present a major cost burden as well as increased morbidity and mortality. Unique among skin tissue engineering technology is the TissueTech autograft system, as it incorporates an autologous dermal substitute—Hyalograft® 3D—and an autologous epidermal replacement, Laserskin® autograft. Each includes a matrix of a hyaluronic acid ester to promote cellular migration and graft take.

Key Words: tissue engineering • hyaluronan • chronic lower extremity wounds • leg ulcers • diabetic foot ulcer • pressure ulcer

The International Journal of Lower Extremity Wounds, Vol. 2, No. 3, 140-151 (2003)
DOI: 10.1177/1534734603258480
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