The International Journal of Lower Extremity Wounds

 

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The International Journal of Lower Extremity Wounds, Vol. 3, No. 2, 69-79 (2004)
DOI: 10.1177/1534734604265431
© 2004 SAGE Publications

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Gene Therapy in the Treatment of Lower Extremity Wounds

Christoph Theopold, MBBS, MA, MRCSEd

Feng Yao, PhD

Elof Eriksson, MD, PhD

Division of Plastic Surgery, Brigham and Women’s Hospital, Boston, MA

This article presents a brief overview of the etiology of chronic wounds of the lower extremities and their current medical and surgical treatment. Gene therapy as a potential tool for treating therapeutically challenging wounds is described in terms of the vectors employed in gene transfer, as well as the strategies used to promote wound healing. Results from animal model studies, as well as clinical trials, are presented.

Key Words: gene transfer • gene therapy • ulcer • growth factor • gene regulation


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