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Wound Healing Potential of Pterocarpus Santalinus Linn: A Pharmacological EvaluationDepartment of Sharira Kriya, J. B. Roy State Ayurvedic Medical College and Hospital, Kolkata, India,
Department of Kayachikitsa, Institute of Postgraduate Ayurvedic Education and Research, Kolkata, India
S. N. Pradhan Centre for Neurosciences, University College of Medicine, Kolkata, India, impuffer{at}cal2.vsnl.net.in The need for new therapeutics for wound healing has encouraged the drive to examine the nature and value of plant products. Ayurveda, the Indian traditional system of medicine, mentions the values of medicinal plants for wound healing. One of these is Pterocarpus santalinus. This article describes a pharmacological study to evaluate its toxicity as well as wound-healing potential in animal studies. Powder made from the wood of the P. santalinus tree was used to make up an ointment in a petroleum jelly base. No toxic effects were observed in 72 hours. Studies were done on punch and burn wound models on normal and diabetic rats using the test ointment, untreated and vehicle controls, and standard therapy. Physical and biochemical measurements were made. The test ointment-treated wounds healed significantly faster. On healing, collagenesis and biochemical measurements yielded supportive data. These studies permit the conclusion that the P. santalinus ointment is safe and effective in treating acute wounds in animal models.
Key Words: wound healing • Pterocarpus santalinus • wound pharmacology • animal models
The International Journal of Lower Extremity Wounds, Vol. 3, No. 3,
143-150 (2004) |
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