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The International Journal of Lower Extremity Wounds
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Inflammation and Wound Healing: The Role of Bacteria in the Immuno-Regulation of Wound Healing

Stuart G. Jones, BSc, MSc, PhD

Oral Surgery, Medicine & Pathology, The Dental School, Cardiff University, Heath Park, Cardiff, UK

Ruth Edwards, BSc, MBBCh, MRCSEng

Wound Healing Research Unit, Cardiff Medicentre, Heath Park, Cardiff, UK

David W. Thomas, FDSRCSEd&Eng, MScD, PhD

Oral Surgery, Medicine & Pathology, The Dental School, Cardiff University, Heath Park, Cardiff, UK, ThomasDW2{at}Cardiff.ac.uk

Wound healing is a sequence of complex events, an imbalance of which can result in a failure of the wound to heal, with significant implications for patients and health care services alike. Although the exact mechanism that underlies these events is not fully understood, inflammatory processes and the innate immune system play a vital role, not only in normal wound healing but also in the pathophysiology of delayed wound healing. These defense mechanisms are affected by underlying disease states and medical conditions, for example, diabetes, venous insufficiency, and the inflammation associated with acute trauma. Importantly, however, these processes are also modulated in health by bacteria within the wound. This article examines the role of the mediators of inflammation involved in the wound-healing process and discusses the function of these mediators when normal healing fails. The reaction of the wound to bacterial contamination and the effect of bacteria on wound healing are also discussed.

Key Words: chronic wounds • bacteria • inflammation

The International Journal of Lower Extremity Wounds, Vol. 3, No. 4, 201-208 (2004)
DOI: 10.1177/1534734604271810
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[Abstract] [Full Text] [PDF]