The International Journal of Lower Extremity Wounds

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jones, S. G.
Right arrow Articles by Thomas, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jones, S. G.
Right arrow Articles by Thomas, D. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The International Journal of Lower Extremity Wounds, Vol. 3, No. 4, 201-208 (2004)
DOI: 10.1177/1534734604271810

Inflammation and Wound Healing: The Role of Bacteria in the Immuno-Regulation of Wound Healing

Stuart G. Jones, BSc, MSc, PhD

Oral Surgery, Medicine & Pathology, The Dental School, Cardiff University, Heath Park, Cardiff, UK

Ruth Edwards, BSc, MBBCh, MRCSEng

Wound Healing Research Unit, Cardiff Medicentre, Heath Park, Cardiff, UK

David W. Thomas, FDSRCSEd&Eng, MScD, PhD

Oral Surgery, Medicine & Pathology, The Dental School, Cardiff University, Heath Park, Cardiff, UK, ThomasDW2{at}Cardiff.ac.uk

Wound healing is a sequence of complex events, an imbalance of which can result in a failure of the wound to heal, with significant implications for patients and health care services alike. Although the exact mechanism that underlies these events is not fully understood, inflammatory processes and the innate immune system play a vital role, not only in normal wound healing but also in the pathophysiology of delayed wound healing. These defense mechanisms are affected by underlying disease states and medical conditions, for example, diabetes, venous insufficiency, and the inflammation associated with acute trauma. Importantly, however, these processes are also modulated in health by bacteria within the wound. This article examines the role of the mediators of inflammation involved in the wound-healing process and discusses the function of these mediators when normal healing fails. The reaction of the wound to bacterial contamination and the effect of bacteria on wound healing are also discussed.

Key Words: chronic wounds • bacteria • inflammation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
L. Braiman-Wiksman, I. Solomonik, R. Spira, and T. Tennenbaum
Novel Insights into Wound Healing Sequence of Events
Toxicol Pathol, October 1, 2007; 35(6): 767 - 779.
[Abstract] [Full Text] [PDF]