SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The International Journal of Lower Extremity Wounds
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Rai, N. K.
Right arrow Articles by Shukla, V. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rai, N. K.
Right arrow Articles by Shukla, V. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reviews

Apoptosis: A Basic Physiologic Process in Wound Healing

Nirendra K. Rai, MD

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Kamlakar Tripathi, MD, DM

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Deborshi Sharma, MS

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Vijay K. Shukla, MS, MCh (Wales)

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, vkshuklabhu{at}satyam.net.in

Apoptosis, or programmed cell death, is a complex network of biochemical pathways for controlling such events in a cell. Apoptosis is essential, as its failure can lead to disease. Because apoptosis concerns the regulation of sequential events, including the removal of inflammatory cells and the evolution of granulation tissue into scar tissue, it has an essential role in wound repair. This article examines the literature and proposes that apoptosis features in the development of diabetic foot wounds. Hyperglycemia deregulates the sequential apoptotic events by multiple mechanisms, leading to delayed wound healing. Deregulated apoptosis is emerging as a prominent cause of delayed wound healing, especially in diabetic wounds, along with the well-known triad of peripheral vascular disease, neuropathy, and infection.

Key Words: apoptosis • wound healing • cell and molecular studies • diabetic wounds • DNA fragmentation

The International Journal of Lower Extremity Wounds, Vol. 4, No. 3, 138-144 (2005)
DOI: 10.1177/1534734605280018
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
M. A. Pallero, C. A. Elzie, J. Chen, D. F. Mosher, and J. E. Murphy-Ullrich
Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis
FASEB J, November 1, 2008; 22(11): 3968 - 3979.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Costa, L. Barberis, C. Ambrogio, A. D. Manazza, E. Patrucco, O. Azzolino, P. O. Neilsen, E. Ciraolo, F. Altruda, G. D. Prestwich, et al.
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase {gamma}
PNAS, September 4, 2007; 104(36): 14354 - 14359.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
S. Elmore
Apoptosis: A Review of Programmed Cell Death
Toxicol Pathol, June 1, 2007; 35(4): 495 - 516.
[Abstract] [Full Text] [PDF]