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The International Journal of Lower Extremity Wounds
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A Review of the Mechanisms Implicated in the Pathogenesis of the Diabetic Foot

Thanh L. Dinh, DPM

Division of Podiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Aristidis Veves, MD, MSc, DSc

Joslin-Beth Israel Deaconess Foot Center and Microcirculation Lab, Harvard Medical School, Boston, MA, aveves{at}bidmc.harvard.edu

The developmental pathway toward diabetic foot ulceration is best described as multifactorial. A critical triad of neuropathy, minor foot trauma, and foot deformity has been identified in greater than 63% of foot ulcers. In addition to these risk factors, increased peak plantar pressures, autonomic and motor neuropathy, limited joint mobility, and impaired wound healing contribute to the formation of diabetic foot ulcers. It is essential to understand the pathogenesis of foot ulcers so that appropriate treatments may be developed.

Key Words: diabetic foot • neuropathy • trauma • joint immobility • microcirculation

The International Journal of Lower Extremity Wounds, Vol. 4, No. 3, 154-159 (2005)
DOI: 10.1177/1534734605280130
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