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The International Journal of Lower Extremity Wounds
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Cecropia peltata L(Cecropiaceae) Has Wound-Healing Potential: A Preclinical Study in a Sprague Dawley Rat Model

B. Shivananda Nayak, MSc, PhD

Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad; Department of Biochemistry, Kasturba Medical College, Manipal, India, snayak{at}fms.uwi.tt

The plant Cecropia peltata is used in traditional medicine to treat a variety of disorders. The objective of the study presented in this report was to screen the extracts of this plant leaf for its wound-healing properties based on its traditional use for wound healing. Aqueous and ethanol extracts were prepared for topical and oral administration. The dose studied was 150 mgkg-1day-1 for 10 days, using the excision wound model in rats. Carboxymethyl cellulose (1%) was used as control in topical and oral route studies. Animals were randomized to treatment or control, the experiment being done with prior ethical approval from the university. Wound areas were measured. On day 11, tissue was excised to determine the contents of protein, hydroxyproline, and hexosamine. Wound areas reduced statistically significantly in all treatment groups compared to respective controls (P < .001). Biochemistry and tissue histology outcomes were consistent with changes in the treatment groups. No differences were detected within the treatment groups. The study permits the conclusion that Crecopia peltata has wound-healing potential.

Key Words: Cecropia peltata • wound healing • excision model • hydroxyproline • hexosamine • granulation tissue

The International Journal of Lower Extremity Wounds, Vol. 5, No. 1, 20-26 (2006)
DOI: 10.1177/1534734606286472
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This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
B. S. Nayak, S. Sandiford, and A. Maxwell
Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf
Evid. Based Complement. Altern. Med., September 1, 2009; 6(3): 351 - 356.
[Abstract] [Full Text] [PDF]


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