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The International Journal of Lower Extremity Wounds
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Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study

Katia Vandenbulcke

Ghent University, Department of Radiopharmacy, Ghent, Belgium

Lada-Ivana Laenen Horvat

Virco-Tibotec, Mechelen, Belgium (formerly Research and Development Flen Pharma, Edegem, Belgium)

Martine De Mil

Ghent University Hospital, Tissue Bank and Department of Dermatology, Ghent, Belgium

Guido Slegers

Ghent University, Department of Radiopharmacy, Ghent, Belgium

Hilde Beele

Ghent University Hospital, Tissue Bank and Department of Dermatology, Ghent, Belgium, Hilde.Beele{at}Ugent.be

Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal® and Flaminal® Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.

Key Words: alginates • antibacterial • hydrogel • leg ulcers • toxicity • wound healing

The International Journal of Lower Extremity Wounds, Vol. 5, No. 2, 109-114 (2006)
DOI: 10.1177/1534734606289507
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