This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Goretti, C. Articles by Piaggesi, A. Search for Related Content PubMed PubMed Citation Articles by Goretti, C. Articles by Piaggesi, A. Social Bookmarking                   What's this?

Clinical Outcomes of Wide Postsurgical Lesions in the Infected Diabetic Foot Managed With 2 Different Local Treatment Regimes Compared Using a Quasi-Experimental Study Design: A Preliminary Communication

Sabrina Mazzurco

Laura Ambrosini Nobili

Silvia Macchiarini

Anna Tedeschi

Francesca Palumbo

Alessia Scatena

Loredana Rizzo

Alberto Piaggesi

Diabetic Foot Section, Department of Endocrinology and Metabolism, University of Pisa, Italy

The safety and efficacy of a novel superoxidized solution (Dermacyn^TM Wound Care [DWC], Oculus Innovative Sciences, Petaluma, Calif) was evaluated for the treatment of wide postsurgical infected ulcers of the diabetic foot. A group (group A,n = 18) of patients with diabetes mellitus who had postsurgical lesions>5 cm² without ischemia or infection were recruited consecutively and treated with DWC-saturated dressings. These dressings were renewed once daily and were compared with a group of patients that had been previously treated with diluted povidone iodine (group B,n = 15) using a quasi-experimental study design. Both sets of patients also received standard systemic antibiotic therapy, as per the practice in this center, and local surgical debridement. Patients had weekly assessments until wounds had re-epithelialized completely. Patients in group A had statistically significant shorter healing time and duration of antibiotic therapy and a higher healing rate at 6 months compared with those in group B (p < .01). Recurrence of infection, requirement for debridement procedures, and requirement for minor amputations were significantly less frequent during follow-up in group A patients (p < .05) when compared with those in group B. These preliminary data suggest that DWC used as a wound dressing together with other local and systemic therapies may have a role in reducing healing time as well as complications in patients with diabetes who have postsurgical lesions of the diabetic foot. These data propose the need for a robust controlled study of DWC-saturated dressings to explore its full potential.

Key Words: superoxidized solution • diabetic foot ulcers • povidone iodine • antimicrobials • antiseptics

The International Journal of Lower Extremity Wounds, Vol. 6, No. 1, 22-27 (2007)
DOI: 10.1177/1534734606298543


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?