The International Journal of Lower Extremity Wounds

 

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The International Journal of Lower Extremity Wounds, Vol. 7, No. 1, 21-27 (2008)
DOI: 10.1177/1534734607314051

Evaluation of Wound-Healing Potential of Pisonia grandis R.Br: A Preclinical Study in Wistar Rats

D. Prabu, MPharm

Department of Pharmacology, C. L. Baid Metha College of Pharmacy, prabu.pharma{at}gmail.com

M. Nappinnai, MPharm

Department of Pharmaceutics, C. L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu

K. Ponnudurai, MPharm

Department of Pharmacology, Pharmacy College Azamgarh, Itaura, Azamgarh

K. Prabhu, MPharm

Department of Pharmacognosy, Nandini Nagar Mahavidyalaya College of Pharmacy, Gonda Uttar Pradesh, India

Pisonia grandis R.Br (family: Nyctaginaceae) is a herb claimed to be used for treatment of inflammation, wound healing, algesia, and ulcer. The present study was done to evaluate the wound-healing potential of methanolic extract of its leaves. Following preliminary photochemical evaluation, the extract was incorporated in simple ointment base and evaluated using 2 types of wound models in Wistar rats—excision wound and incision wound. The results were significantly different ( p <0.05) when compared with control group for wound contraction, tensile strength, and histopathological and biological parameters. Antibacterial studies against different bacterial strains of the test samples were performed by the disk-diffusion method and were compared with standard ofloxacin and erythromycin. Test sample showed comparable zone of inhibition to the standards. It is hypothesized that the presence of phytoconstituents with the antibacterial effect helps in wound healing.

Key Words: Pisonia grandis • wound healing • incision • excision • antibacterial • Wistar rat


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