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Use of Nanotechnology-Designed Footsock in the Management of Preulcerative Conditions in the Diabetic Foot: Results of a Single, Blind Randomized Study

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Macchiarini Silvia, DPM

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Dini Valentina, MD

Department of Surgery, Dermatologic Clinic University of Pisa, Italy

Rizzo Loredana, MD

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Tedeschi Anna, MD

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Scatena Alessia, MD

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Goretti Chiara, MD

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Campi Fabrizio, MD

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa

Romanelli Marco, MD

Department of Surgery, Dermatologic Clinic University of Pisa, Italy

Alberto Piaggesi, MD

Department of Endocrinology and Metabolism, Diabetic Foot Section, University of Pisa, piaggesi{at}immr.med.unipi.it

The Difoprev system constituted by a sock loaded with nanocapsules containing a hydrating agent in the diabetic foot is tested. A total of 30 neuropathic outpatients with foot anhydrosis were randomized into group A, treated with the application of the sock with the nanocapsules, and group B wearing only the socks without the nanocapsules. Patients were blindly evaluated with a clinical score, hygrometry, transepidermal water loss, skin temperature, and skin hardness at baseline and after 6 weeks. No difference between the groups emerged at baseline. Although group B showed no changes at the end of the treatment, group A significantly ( P < .05) improved in all the parameters evaluated. No adverse events were recorded in both groups during the study. The use of hydrating agents carried by nanocapsules-loaded socks is safe and effective for the neuropathic diabetic foot.

Key Words: diabetic foot • nanotechnologies • ulcer • measurements • skin hydration

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