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The International Journal of Lower Extremity Wounds
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*Substance via MeSH
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*Scars
*Steroids
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The Use of Corticosteroids to Treat Keloids: A Review

Claude Roques, MD

Pediatric Rehabilitation Centre, CSRE Lamalou le Haut, Lamalou les Bains, France, clauderoques{at}aol.com

Luc Téot, MD

Burn and Plastic Surgery Unit, Hôpital Lapeyronie, Montpellier, France

Mechanisms for keloid formation include drastic changes in growth factor actions, collagen turnover, mechanical forces applied over the skin, and genetic and immunologic contributions. The use of corticosteroids to manage keloids increases basic fibroblast growth factor production while decreasing transforming growth factor-β1 production by human dermal fibroblasts, endogenous vascular endothelial growth factor, and insulin-like growth factor-1. The use of corticosteroid injections is, to date, the core treatment available for the management of excessive tissue production in scars. Currently, the most effective and safe regimen for keloid management appears to be the use of corticotherapy—injection of intradermal steroids after a surgical excision.

Key Words: corticosteroids • keloid • hypertrophic scars • triamcinolone acetonide

This version was published on September 1, 2008

The International Journal of Lower Extremity Wounds, Vol. 7, No. 3, 137-145 (2008)
DOI: 10.1177/1534734608320786
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