SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The International Journal of Lower Extremity Wounds
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1534734608320786v1
7/3/137    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Roques, C.
Right arrow Articles by Téot, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roques, C.
Right arrow Articles by Téot, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reviews

The Use of Corticosteroids to Treat Keloids: A Review

Claude Roques, MD

Pediatric Rehabilitation Centre, CSRE Lamalou le Haut, Lamalou les Bains, France, clauderoques{at}aol.com

Luc Téot, MD

Burn and Plastic Surgery Unit, Hôpital Lapeyronie, Montpellier, France

Mechanisms for keloid formation include drastic changes in growth factor actions, collagen turnover, mechanical forces applied over the skin, and genetic and immunologic contributions. The use of corticosteroids to manage keloids increases basic fibroblast growth factor production while decreasing transforming growth factor-β1 production by human dermal fibroblasts, endogenous vascular endothelial growth factor, and insulin-like growth factor-1. The use of corticosteroid injections is, to date, the core treatment available for the management of excessive tissue production in scars. Currently, the most effective and safe regimen for keloid management appears to be the use of corticotherapy—injection of intradermal steroids after a surgical excision.

Key Words: corticosteroids • keloid • hypertrophic scars • triamcinolone acetonide

This version was published on September 1, 2008

The International Journal of Lower Extremity Wounds, Vol. 7, No. 3, 137-145 (2008)
DOI: 10.1177/1534734608320786
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?