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Evidence-Based Recommendations for the Use of Topical Oxygen Therapy in the Treatment of Lower Extremity Wounds

Division of Plastic Surgery, Department of Surgery, College of Medicine, gayle.gordillo{at}osumc.edu

Chandan K. Sen, PhD

Davis Heart and Lung Research Institute The Ohio State University, Columbus, Ohio

Topical oxygen therapy provides another tool in the armamentarium of clinicians treating refractory lower extremity wounds. Devices suitable for providing topical oxygen therapy in a clinical setting have recently become available. This article reviews the evidence to justify the use of this treatment modality, including in vitro, preclinical data, and clinical data. It also provides a protocol for how to administer topical oxygen therapy as well as guidance on patient selection and management to optimize outcomes. Randomized controlled trials are not yet reported and clearly necessary. The current body of evidence suggests that topical oxygen therapy may be considered as a second line of therapy for refractory wounds.

Key Words: oxygen • reactive oxygen species • angiogenesis • wound

The International Journal of Lower Extremity Wounds, Vol. 8, No. 2, 105-111 (2009)
DOI: 10.1177/1534734609335149


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