This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nayak, B. S. Search for Related Content PubMed PubMed Citation Articles by Nayak, B. S. Social Bookmarking                         What's this?

Cecropia peltata L(Cecropiaceae) Has Wound-Healing Potential: A Preclinical Study in a Sprague Dawley Rat Model

Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad; Department of Biochemistry, Kasturba Medical College, Manipal, India, snayak{at}fms.uwi.tt

The plant Cecropia peltata is used in traditional medicine to treat a variety of disorders. The objective of the study presented in this report was to screen the extracts of this plant leaf for its wound-healing properties based on its traditional use for wound healing. Aqueous and ethanol extracts were prepared for topical and oral administration. The dose studied was 150 mgkg^-1day^-1 for 10 days, using the excision wound model in rats. Carboxymethyl cellulose (1%) was used as control in topical and oral route studies. Animals were randomized to treatment or control, the experiment being done with prior ethical approval from the university. Wound areas were measured. On day 11, tissue was excised to determine the contents of protein, hydroxyproline, and hexosamine. Wound areas reduced statistically significantly in all treatment groups compared to respective controls (P < .001). Biochemistry and tissue histology outcomes were consistent with changes in the treatment groups. No differences were detected within the treatment groups. The study permits the conclusion that Crecopia peltata has wound-healing potential.

Key Words: Cecropia peltata • wound healing • excision model • hydroxyproline • hexosamine • granulation tissue

References

• Clark RA. Fibrin and wound healing. Ann N Y Acad Sci 2001;936:355-367.[Medline] [Order article via Infotrieve]
• Lawrence WT, Diegelmann RF. Growth factors in wound healing. Clin Dermatol 1994;12(1):157-169.[CrossRef][Medline] [Order article via Infotrieve]
• Ross R. Wound healing. Sci Am 1969;220(6):40-50.[Medline] [Order article via Infotrieve]
• Prockop DJ, Kivirikko KI. Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem 1995;64:403-434.[CrossRef][Medline] [Order article via Infotrieve]
• Caceres A, Menendez E, Mendez E, et al. Antigonorrhoeal activity of plants used in Guatemala for the treatment of sexually transmitted diseases. J Ethnopharmacol 1995;48(2):85-88.[CrossRef][Medline] [Order article via Infotrieve]
• Little EL Jr, Wadsworth FH. Common trees of Puerto Rico and the Virgin Islands [Agriculture Handbook 249]. Washington, DC: U.S. Department of Agriculture; 1964:548.
• Forest RD. Development of wound therapy from dark ages to the present. J R Soc Med 1982;75(4):268-273.[Medline] [Order article via Infotrieve]
• Morton JJ, Malone MH. Evaluation of vulnerary activity by an open procedure in rats. Arch Int Pharmacodyn Ther 1972;196:117-126.
• Patil PA, Kulkarni DR. Effect of antiproliferative agents on healing of dead space wounds in rats. Ind J Med Res 1984;79:445-447.[Medline] [Order article via Infotrieve]
• Diwan PV, Tilloo LD, Kulkarni DR. Influence of Tridax procumbens on wound healing. Ind J Med Res 1982;75:460-464.[Medline] [Order article via Infotrieve]
• Lowry OH, Rosenbrough NJ, Farr AL, Randall BJ. Protein measurement Folin phenol reagent. J Biol Chem 1951;193:265-275.[Free Full Text]
• Neuman RE, Logan MA. The determination of hydroxyproline. J Biol Chem 1950;184(1):299-306.[Free Full Text]
• Elson LA, Morgan WTJ. Colorimetric method for the determination of glucosamine and chondrosamine. Biochem J 1933;27:1824-1828.
• Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing: oral and topical activity of aloe vera. J Am Pediatr Med Assoc 1989;79:559-562.
• Davis RH, Kabbani JM, Maro NP. Aloe vera-wound healing. J Am Podiatr Med Assoc 1987;77(4):165-169.[Medline] [Order article via Infotrieve]
• Nayak BS, Suresh Rao AVC, Pillai GK, Davis EM, Ramkissoon V, McAre A. "Evaluation of wound healing activity of Vanda roxburghii R.Br (Orchidacea)—a preclinical study in a rat model. Int J Lower Extremity Wounds 2005;4:200-204.[CrossRef]
• King NM, Haddock N. A note on the phytochemical investigation of Cecropia peltata L. Am Pharm Assoc Am Pharm Assoc (Baltim) 1959;80(48):39-43.

The International Journal of Lower Extremity Wounds, Vol. 5, No. 1, 20-26 (2006)
DOI: 10.1177/1534734606286472


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. S. Nayak, S. Sandiford, and A. Maxwell Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf Evid. Based Complement. Altern. Med., September 1, 2009; 6(3): 351 - 356. [Abstract] [Full Text] [PDF]

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nayak, B. S. Search for Related Content PubMed PubMed Citation Articles by Nayak, B. S. Social Bookmarking                         What's this?