SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The International Journal of Lower Extremity Wounds
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Dini, V.
Right arrow Articles by Mosca, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dini, V.
Right arrow Articles by Mosca, F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reviews

Cutaneous Tissue Engineering and Lower Extremity Wounds (Part 2)

Valentina Dini, MD

Department of Dermatology, University of Pisa, Pisa, Italy

Marco Romanelli, MD, PhD

Department of Dermatology, University of Pisa, Pisa, Italy, m.romanelli{at}med.unipi.it

Alberto Piaggesi, MD

Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

Alessandro Stefani, MD, PhD

Department of Oncology and Transplantation, University of Pisa, Pisa, Italy

Franco Mosca, MD

Department of Oncology and Transplantation, University of Pisa, Pisa, Italy

In a previous article, this group described the principles involved in the development of bioengineered skin equivalents that held out much promise. This article has examined some of the uses of such products in treating venous ulcers, diabetic foot ulcers, and skin diseases leaving skin wounds. Data encouraging the use of such products in certain indications are available. The costs of using such products are also appreciated.

Key Words: chronic venous ulcers • diabetic foot ulcers • skin diseases • bioengineered skin equivalents • wound healing

References

  • Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen 2000;8:347-352.[CrossRef][Medline] [Order article via Infotrieve]
  • Boschi E, Longoni BM, Romanelli M, Mosca F. Cutaneous tissue engineering and lower extremity wounds (Part 1). Int J Lower Extremity Wounds 2004;3(2):80-86.
  • Jimenez PA, Jimenez SE. Tissue and cellular approaches to wound repair. Am J Surg 2004;187(Suppl. May):56S-64S.[CrossRef][Medline] [Order article via Infotrieve]
  • Jahoda CA, Reynolds AJ. Hair follicle dermal sheath cells: unsung participants in wound healing. Lancet 2001;358:1445-1448.[CrossRef][Medline] [Order article via Infotrieve]
  • Eaglstein WH, Alvarez OM, Auletta M, et al. A composite skin substitute (Graftskin®) for surgical wounds: a clinical experience. Dermatol Surg 1995;21:839-843.[CrossRef][Medline] [Order article via Infotrieve]
  • Mansbridge J, Liu K, Patch R, Symons K, Pinney E. Three-dimensional fibroblast culture implant for the treatment of diabetic foot ulcers: metabolic activity and therapeutic range. Tissue Eng 1998;4:403-414.[Medline] [Order article via Infotrieve]
  • Phillips TJ, Dover JS. Leg ulcers. J Am Acad Dermatol 1991;25:965-987.[Medline] [Order article via Infotrieve]
  • Bell E, Ehrlich HP, Buttle DJ, Nakatsuji T. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science 1981;211:1052-1054.[Abstract/Free Full Text]
  • Leigh IM, Purkis PE, Navsaria HA, Phillips TJ. Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br J Dermatol 1987;117:591-597.[CrossRef][Medline] [Order article via Infotrieve]
  • Sabolinski ML, Alvarez O, Auletta M, Mulder G, Parenteau NL. Cultured skin as a ‘smart material’ for healing wounds: experience in venous ulcers. Biomaterials 1996;17:311-320.[CrossRef][Medline] [Order article via Infotrieve]
  • Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogenic cultured human skin equivalent. Arch Dermatol 1998;134:293-300.[Abstract/Free Full Text]
  • Falanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF®) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen 1999;7:201-207.[CrossRef][Medline] [Order article via Infotrieve]
  • Milstone LM, Asgari MM, Schwartz PM. Growth factor expression, healing and structural characteristics of Graftskin (Apligraf®). Wounds 2000;12(Suppl A):12A-19A.
  • Omar AA, Mavor AID, Jones AM, Homer-Vanniasinkam S. Treatment of venous leg ulcers with Dermagraft®. Eur J Endovasc Surg 2004;27:666-672.
  • Tausche AK, Skaria M, Bohlen L, et al. An autologous epidermal equivalent tissue-engineered from follicular outer sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers. Wound Repair Regen 2003;11:248-252.[CrossRef][Medline] [Order article via Infotrieve]
  • Mostow EN, Haraway GD, Dalsing M, et al. Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial. J Vasc Surg 2005;41:837-843.[CrossRef][Medline] [Order article via Infotrieve]
  • Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 1994;130(4):489-493.[Abstract/Free Full Text]
  • Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing. Arch Surg 2000;135:627-634.[Abstract/Free Full Text]
  • Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. BMJ 2002;324:160-163.[Free Full Text]
  • Apelqvist J, Larsson J. What is the most effective way to reduce the incidence of amputation in the diabetic foot? Diabetes Metab Res Rev 2000;16(Suppl 1):S75-S83.[CrossRef][Medline] [Order article via Infotrieve]
  • Boulton AJM. Clinical presentation and management of diabetic neuropathy and foot ulceration. Diabet Med 1991;8:552-557.
  • Reiber GE, Vileikyte L, Boyko EJ, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999;22:157-162.[Abstract/Free Full Text]
  • Gentzkow GD, Iwasaki SD, Hershon KS, et al. Use of Dermagraft, a cultural human dermis, to treat diabetic foot ulcers. Diabetes Care 1996;19:350-354.[Abstract]
  • Veves A, Falanga V, Armstrong DG, Sabolinski ML. Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers. A prospective randomized multicenter clinical trial. Diabetes Care 2001;24:290-295.[Abstract/Free Full Text]
  • Caravaggi C, Faglia E, De Giglio R, et al. Effectiveness and safety of a non-removable fiberglass off-bearing cast versus a therapeutic shoe in the treatment of neuropathic foot ulcers. Diabetes Care 2000;23:1746-1751.[Abstract/Free Full Text]
  • Armstrong DG, Ngyugen HC, Lavery LA, et al. Off-loading the diabetic foot wound: a randomized clinical trial. Diabetes Care 2001;24:1019-1022.[Abstract/Free Full Text]
  • Piaggesi A, Viacava P, Rizzo L, et al. Semiquantitative analysis of the histopathological features of the neuropathic foot ulcer: effect of pressure relief. Diabetes Care 2003;26:3123-3128.[Abstract/Free Full Text]
  • Caravaggi C, De Giglio R, Pritelli C, et al. HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers. A prospective, multicenter, controlled, randomised clinical trial. Diabetes Care 2003;26:2853-2859.[Abstract/Free Full Text]
  • Piaggesi A, Baccetti F, Rizzo L, Romanelli M, Navalesi R, Benzi L. Sodium carboxyl-methyl-cellulose dressings in the management of deep ulcerations of diabetic foot. Diabet Med 2001;18(4):320-324.[CrossRef][Medline] [Order article via Infotrieve]
  • Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW. Assessment and management of foot disease in patients with diabetes. N Engl J Med 1994;331:854-860.[Free Full Text]
  • Uccioli L. Clinical results related to the use of tissuetech autograft system in the treatment of diabetic foot ulceration. Wounds 2003;15:279-288.
  • Phillips TJ, Bigby M, Bercovitch L. Cultured allografts as an adjunct to the medical treatment of problematic leg ulcers. Arch Dermatol 1991;127:799-801.[Abstract/Free Full Text]
  • De Imus G, Golomb C, Wilkel C, Tsoukas M, Nowak M, Falanga V. Accelerated healing of pyoderma gangrenosum treated with bioengineered skin and concomitant immunosuppression. J Am Acad Dermatol 2001;144:61-66.[CrossRef]
  • Pennoyer JW, Susser WS, Chapman MS. Ulcers associated with polyarteritis nodosa treated with bioengineered human skin equivalent (Apligraf®). J Am Acad Dermatol 2002;46:145.
  • Drosou A, Kirsner RS, Kato T, et al. Use of a bioengineered skin equivalent for the management of difficult skin defects after pediatric multivisceral transplantation. J Am Acad Dermatol 2005;52:854-858.[CrossRef][Medline] [Order article via Infotrieve]
  • Charles CA, Kato T, Tzakis AG, Miller BN, Kirsner RS. Use of a living dermal equivalent for a refractory abdominal defect after pediatric multivisceral transplantation. Dermatol Surg 2004;30(9):1236-1240.[CrossRef][Medline] [Order article via Infotrieve]
  • Falabella AF, Schachner LA, Valencia IC, Eaglstein WH. The use of tissue-engineered skin (Apligraf) to treat a newborn with Epidermolysis bullosa. Arch Dermatol 1999;135:1219-1222.[Abstract/Free Full Text]
  • Wollina U, Konrad H, Fischer T. Recessive epidermolysis bullosa dystrophicans (Hallopeau-Siemens): improvement of wound healing by autologous epidermal grafts on an esterified hyaluronic acid membrane. J Dermatol 2001;28(4):217-220.[Medline] [Order article via Infotrieve]
  • Flores F, Eaglstein WH, Kirsner RS. Hydroxyurea-induced leg ulcers treated with Apligraf. Ann Intern Med 2000;132:417.[Free Full Text]

The International Journal of Lower Extremity Wounds, Vol. 5, No. 1, 27-34 (2006)
DOI: 10.1177/1534734606286464
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Dini, V.
Right arrow Articles by Mosca, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dini, V.
Right arrow Articles by Mosca, F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Advertisement