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The International Journal of Lower Extremity Wounds
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Reviews

Outcome Measurements in Wound Healing Are Not Inclusive: A Way Forward

S. Matousek

Department of Plastic and Maxillofacial Surgery, Liverpool Hospital and South Western Clinical School University of New South Wales, Sydney, Australia

A.K. Deva

Department of Plastic and Maxillofacial Surgery, Liverpool Hospital and South Western Clinical School University of New South Wales, Sydney, Australia, Ananddeva{at}unsw.edu.au

Raj Mani, PhD, FACA, DTech

Division of Diagnostics and Therapeutics, Southampton University Hospitals NHS Trust, Southampton, UK

Standardized outcome measurement in wound healing has been an elusive goal. Whilst research into wound healing science and technology continues to progress rapidly, the lack of a uniform outcome assessment is making comparative analysis of results difficult. This paper seeks to outline the reported clinical, physiological, and histological outcomes that have been utilized in the literature. A minimal data set base for wound outcome evaluation is also established to be validated by future multivariate analysis of patient data.

Key Words: wound • outcome • measurement

References

  • Bulstrode CJ, Goode AW, Scott PJ Measurement and prediction of progress in delayed wound healing . J R Soc Med 1987;80: 210-2 .[Abstract]
  • Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pecoraro RE, Rodeheaver G., et al. Definitions and guidelines for assessment of wounds and evaluation of healing . Arch Dermatol 1994;130: 489-93 .[Abstract/Free Full Text]
  • Price P. The challenge of outcome measures in chronic wounds . J Wound Care. 1999;8: 306-8 .[Medline] [Order article via Infotrieve]
  • Franz MG, Kuhn MA, Wright TE, Wachtel TL, Robson MC Use of the wound healing trajectory as an outcome determinant for acute wound healing . Wound Repair Regen 2000;8: 511-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Keast DH, Cranney G. Does wound surface area as measured by length and width reflect true area: analysis of wound data base . Canadian Association of Wound Care Conference, Toronto, 6—9 Nov, 2003.
  • Steed DL, Hill DP, Woodske ME, Payne WG, Robson MC Wound-healing trajectories as outcome measures of venous stasis ulcer treatment . Int Wound J 2006;3: 40-7 .[CrossRef][Medline] [Order article via Infotrieve]
  • Hayward PG, Hillman GR, Quast MJ, Robson MC Surface area measurement of pressure sores using wound molds and computerized imaging . J Am Geriatr Soc 1993;41: 238-40 .[Medline] [Order article via Infotrieve]
  • Thawer HA, Houghton PE, Woodbury MG, Keast D., Campbell K. A comparison of computer-assisted and manual wound size measurement . Ostomy Wound Manage 2002;48: 46-53 .[Medline] [Order article via Infotrieve]
  • Bahmer FA Wound measurement made truly simple by point counting . Arch Dermatol 1999;135: 991-2 .[Free Full Text]
  • Haghpanah S., Bogie K., Wang X., Banks PG, Ho CH Reliability of electronic versus manual wound measurement techniques . Arch Phys Med Rehabil 2006;87: 1396-402 .[CrossRef][Medline] [Order article via Infotrieve]
  • Flanagan M. Improving accuracy of wound measurement in clinical practice . Ostomy Wound Manage 2003;49: 28-40 .[Medline] [Order article via Infotrieve]
  • Gorin DR, Cordts PR, LaMorte WW, Manzoian JO The influence of wound geometry on the measurement of wound healing rates in clinical trials . J Vasc Surg 1996;23: 524-8 .[CrossRef][Medline] [Order article via Infotrieve]
  • Sheehan P., Jones P., Caselli A., Giurini JM, Veves A. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial . Diabetes Care 2003;26: 1879-82 .[Abstract/Free Full Text]
  • Langemo DK, Melland H., Olson B., Hanson D., Hunter S., Henly SJ, et al. Comparison of 2 wound volume measurement methods . Adv Skin Wound Care 2001;14: 190-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Langemo DK, Melland H., Hanson D., Olson B., Hunter S., Henly SJ Two-dimensional wound measurement: comparison of 4 techniques . Adv Wound Care 1998;11: 337-43 .[Medline] [Order article via Infotrieve]
  • Moore K. Using wound area measurement to predict and monitor response to treatment of chronic wounds . J Wound Care 2005;14: 229-32 .[Medline] [Order article via Infotrieve]
  • Krouskop TA, Baker R., Wilson MS A noncontact wound measurement system . J Rehabil Res Dev 2002;39: 337-45 .[Medline] [Order article via Infotrieve]
  • Lagan KM, Dusoir AE, McDonough SM, Baxter GD Wound measurement: the comparative reliability of direct versus photographic tracings analyzed by planimetry versus digitizing techniques . Arch Phys Med Rehabil 2000;81: 1110-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Williams C. The Verge Videometer wound measurement package . Br J Nurs 2000;9: 237-9 .[Medline] [Order article via Infotrieve]
  • Gethin G., Cowman S. Wound measurement comparing the use of acetate tracings and Visitrak digital planimetry . J Clin Nurs 2006;15: 422-7 .[CrossRef][Medline] [Order article via Infotrieve]
  • Korber A., Rietkotter J., Grabbe S., Dissemond J. Three-dimensional documentation of wound healing: first results of a new objective method for measurement J Dtsch Dermatol Ges 2006;4: 848-54 .[CrossRef][Medline] [Order article via Infotrieve]
  • Cukjati D., Rebersek S., Karba R., Miklavcic D. Modelling of chronic wound healing dynamics . Med Biol Eng Comput 2000;38: 339-47 .[CrossRef][Medline] [Order article via Infotrieve]
  • Robson MC, Maggi SP, Smith PD, Wassermann RJ, Mosiello GC, Hill DP, et al. Original articles: ease of wound closure as an endpoint of treatment efficacy . Wound Repair Regen 1999;7: 90-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Moore K., McCallion R., Searle RJ, Stacey MC, Harding KG Prediction and monitoring the therapeutic response of chronic dermal wounds . Int Wound J 2006;3: 89-96 .[CrossRef][Medline] [Order article via Infotrieve]
  • Reddy M., Keast D., Fowler E., Sibbald RG Pain in pressure ulcers . Ostomy Wound Manage 2003;49: 30-5 .[Medline] [Order article via Infotrieve]
  • Persoon A., Heinen MM, van der Vleuten CJ, de Rooij MJ, van de Kerkhof PC, van Achterberg T. Leg ulcers: a review of their impact on daily life . J Clin Nurs 2004;13: 341-54 .[CrossRef][Medline] [Order article via Infotrieve]
  • Price P., Harding K. Cardiff Wound Impact Schedule: the development of a condition-specific questionnaire to assess health-related quality of life in patients with chronic wounds of the lower limb . Int Wound J 2004;1: 10-7 .[CrossRef][Medline] [Order article via Infotrieve]
  • Bentley J. Improving quality of life in venous leg ulceration: a case study . Br J Nurs 2006;15: S4-8 .[Medline] [Order article via Infotrieve]
  • Goodridge D., Trepman E., Sloan J., Guse L., Strain LA, McIntyre J., et al. Quality of life of adults with unhealed and healed diabetic foot ulcers . Foot Ankle Int 2006;27: 274-80 .[Medline] [Order article via Infotrieve]
  • Fleck CA Differentiating MMPs, biofilm, endotoxins, exotoxins, and cytokines . Adv Skin Wound Care 2006;19: 77-81 .[CrossRef][Medline] [Order article via Infotrieve]
  • Mwaura B., Mahendran B., Hynes N., Defreitas D., Avalos G., Adegbola T., et al. The impact of differential expression of extracellular matrix metalloproteinase inducer, matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2 and PDGF-AA on the chronicity of venous leg ulcers . Eur J Vasc Endovasc Surg 2006;31: 306-10 .[CrossRef][Medline] [Order article via Infotrieve]
  • Ravanti L., Kahari VM Matrix metalloproteinases in wound repair (review) . Int J Mol Med 2000;6: 391-407 .[Medline] [Order article via Infotrieve]
  • Armstrong DG, Jude EB The role of matrix metalloproteinases in wound healing . J Am Podiatr Med Assoc 2002;92: 12-8 .[Abstract/Free Full Text]
  • Lobmann R., Ambrosch A., Schultz G., Waldmann K., Schiweck S., Lehnert H. Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients . Diabetologia 2002;45: 1011-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Moses MA, Marikovsky M., Harper JW, Vogt P., Eriksson E., Klagsbrun M., et al. Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing . J Cell Biochem 1996;60: 379-86 .[CrossRef][Medline] [Order article via Infotrieve]
  • Paddock HN, Schultz GS, Perrin KJ Clinical assessment of silver coated antimicrobial dressings on MMPs and cytokine levels in non-healing wounds . Annual Meeting of the Wound Healing Society, Baltimore, May 28—June 1, 2002.
  • Tarlton JF, Bailey AJ, Crawford E., Jones D., Moore K., Harding KD Prognostic value of markers of collagen remodeling in venous ulcers . Wound Repair Regen 1999;7: 347-55 .[CrossRef][Medline] [Order article via Infotrieve]
  • Mandal A. Burn wound depth assessment: is laser Doppler imaging the best measurement tool available? Int Wound J 2006;3: 138-43 .[CrossRef][Medline] [Order article via Infotrieve]
  • Pape SA, Skouras CA, Byrne PO An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth . Burns 2001;27: 233-9 .[CrossRef][Medline] [Order article via Infotrieve]
  • Bishop JF Burn wound assessment and surgical management . Crit Care Nurs Clin North Am 2004;16: 145-77 .[CrossRef][Medline] [Order article via Infotrieve]
  • Devgan L., Bhat S., Aylward S., Spence RJ Modalities for the assessment of burn wound depth . J Burns Wounds 2006;5: e2 .[Medline] [Order article via Infotrieve]
  • La Hei ER, Holland AJ, Martin HC Laser Doppler imaging of paediatric burns: burn wound outcome can be predicted independent of clinical examination . Burns 2006;32: 550-3 .[CrossRef][Medline] [Order article via Infotrieve]
  • McGill DJ, Sorensen K., Mackay IR, Taggart I., Watson SB Assessment of burn depth: a prospective, blinded comparison of laser Doppler imaging and videomicroscopy . Burns 2007;4.
  • Yablon SA, Novick ES, Jain SS, Inhoffer M., Graves DE Postoperative transcutaneous oxygen measurement in the prediction of delayed wound healing and prosthetic fitting among amputees during rehabilitation. A pilot study . Am J Phys Med Rehabil 1995;74: 193-8 .[CrossRef][Medline] [Order article via Infotrieve]
  • Chang N., Goodson WH, 3rd, Gottrup F, Hunt TK. Direct measurement of wound and tissue oxygen tension in postoperative patients . Ann Surg 1983;197: 470-8 .[Medline] [Order article via Infotrieve]
  • Gibbery A., Mani R. pH in leg ulcers . Int J Microcirc Clin Exp 1992;11(S109).
  • Roberts GH, Hammad L., Collins CS, Shearman CP, Mani R. Some effects of sustained compression of ulcerated tissues . Angiology 2002;53: 451-6 .[Medline] [Order article via Infotrieve]
  • Thompson LW, Zook EG, Hugo NE A tensiometer to measure wound tensile strength in situ . J Surg Res 1969;9: 543-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Charles D., Williams K., 3rd, Perry LC, Fisher J, Rees RS. An improved method of in vivo wound disruption and measurement . J Surg Res 1992;52: 214-8 .[CrossRef][Medline] [Order article via Infotrieve]
  • Hollander DA, Erli HJ, Theisen A., Falk S., Kreck T., Muller S. Standardized qualitative evaluation of scar tissue properties in an animal wound healing model . Wound Repair Regen 2003;11: 150-7 .[CrossRef][Medline] [Order article via Infotrieve]
  • Salcido R. The future of wound measurement . Adv Skin Wound Care 2000;13: 54-6 .[Medline] [Order article via Infotrieve]
  • Mani R., White JE, Barrett DF, Weaver PW Tissue oxygenation, venous ulcers and fibrin cuffs . J R Soc Med 1989;82: 345-6 .[Abstract]
  • Mani R., Gorman FW, White JE Transcutaneous measurements of oxygen tension at edges of leg ulcers: preliminary communication . J R Soc Med 1986;79: 650-4 .[Abstract]
  • Mani R. The significance of tissue oxygen measurements in patients with venous ulcers . Scripta Phlebologica 1995;3: 48-51 .
  • Muangman P., Deubner H., Honari S., Heimbach DM, Engrav LH, Klein MB, et al. Correlation of clinical outcome of integra application with microbiologic and pathological biopsies . J Trauma 2006;61: 1212-7 .[Medline] [Order article via Infotrieve]
  • Vowden K. Common problems in wound care: wound and ulcer measurement . Br J Nurs 1995;4: 775-6 .[Medline] [Order article via Infotrieve]
  • Bruce J., Russell EM, Mollison J., Krukowski ZH The quality of measurement of surgical wound infection as the basis for monitoring: a systematic review . J Hosp Infect 2001;49: 99-108 .[CrossRef][Medline] [Order article via Infotrieve]
  • Penhallow K. A review of studies that examine the impact of infection on the normal wound-healing process . J Wound Care 2005;14: 123-6 .[Medline] [Order article via Infotrieve]
  • Edwards R., Harding KG Bacteria and wound healing . Curr Opin Infect Dis 2004;17: 91-6 .[CrossRef][Medline] [Order article via Infotrieve]
  • Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds . Wound Repair Regen 2000;8: 347-52 .[CrossRef][Medline] [Order article via Infotrieve]
  • Svensjo T., Yao F., Pomahac B., Winkler T., Eriksson E. Cultured autologous fibroblasts augment epidermal repair . Transplantation 2002;73: 1033-41 .[CrossRef][Medline] [Order article via Infotrieve]
  • Robson MC, Dubay DA, Wang X., Franz MG Effect of cytokine growth factors on the prevention of acute wound failure . Wound Repair Regen 2004;12: 38-43 .[CrossRef][Medline] [Order article via Infotrieve]
  • Cooper L., Johnson C., Burslem F., Martin P. Wound healing and inflammation genes revealed by array analysis of `macrophageless' PU.1 null mice . Genome Biol 2005;6: R5 .[CrossRef][Medline] [Order article via Infotrieve]
  • Cole J., Tsou R., Wallace K., Gibran N., Isik F. Early gene expression profile of human skin to injury using high-density cDNA microarrays . Wound Repair Regen 2001;9: 360-70 .[CrossRef][Medline] [Order article via Infotrieve]
  • Gibran NS, Isik FF Use of high-throughput microarray membranes for cDNA analysis of cutaneous wound repair . Methods Mol Med 2003;78: 425-32 .[Medline] [Order article via Infotrieve]
  • Grose R. Common ground in the transcriptional profiles of wounds and tumors . Genome Biol 2004;5: 228 .[CrossRef][Medline] [Order article via Infotrieve]
  • Robson MC, Barbul A. Guidelines for the best care of chronic wounds . Wound Repair Regen 2006;14: 647-8 .[CrossRef][Medline] [Order article via Infotrieve]
  • Obermayer A., Gostl K., Walli G., Benesch T. Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs . J Vasc Surg 2006;44: 572-9 .[CrossRef][Medline] [Order article via Infotrieve]
  • Akopian G., Nunnery SP, Piangenti J., Rankin P., Rinoie C., Lee E., et al. Outcomes of conventional wound treatment in a comprehensive wound center . Am Surg 2006;72: 314-7 .[Medline] [Order article via Infotrieve]
  • Keast DH, Bowering CK, Evans AW, Mackean GL, Burrows C., D'Souza L. MEASURE: A proposed assessment framework for developing best practice recommendations for wound assessment . Wound Repair Regen 2004;12: S1-17 .[CrossRef][Medline] [Order article via Infotrieve]
  • Falanga V., Saap LJ, Ozonoff A. Wound bed score and its correlation with healing of chronic wounds . Dermatol Ther 2006;19: 383-90 .[CrossRef][Medline] [Order article via Infotrieve]
  • Phillips TJ, Machado F., Trout R., Porter J., Olin J., Falanga V. Prognostic indicators in venous ulcers . J Am Acad Dermatol 2000;43: 627-30 .[CrossRef][Medline] [Order article via Infotrieve]
  • Tallman P., Muscare E., Carson P., Eaglstein WH, Falanga V. Initial rate of healing predicts complete healing of venous ulcers . Arch Dermatol 1997;133: 1231-4 .[Abstract/Free Full Text]
  • Bouamra O., Wrotchford A., Hollis S., Vail A., Woodford M., Lecky F. Outcome prediction in trauma . Injury 2006;37: 1092-7 .[CrossRef][Medline] [Order article via Infotrieve]
  • Bosse MJ, MacKenzie EJ, Kellam JF, Burgess AR, Webb LX, Swiontkowski MF, et al. A prospective evaluation of the clinical utility of the lower-extremity injury-severity scores . J Bone Joint Surg Am 2001;83: 3-14 .[Abstract/Free Full Text]
  • Battiston B., Tos P., Pontini I., Ferrero S. Lower limb replantations: indications and a new scoring system . Microsurgery 2002; 22: 187-92 .[CrossRef][Medline] [Order article via Infotrieve]
  • Katzman SS, Dickson K. Determining the prognosis for limb salvage in major vascular injuries with associated open tibial fractures . Orthop Rev 1992;21: 195-9 .[Medline] [Order article via Infotrieve]
  • Victoria CG, Huttly SR, Fuchs SC, Olinto Mta. The role of conceptual frameworks in epidemiological analysis: a hierachical approach . Int J Epidemiol 1997;26: 224-7 .[Abstract/Free Full Text]
  • Bates-Jensen BM Chronic wound assessment . Nurs Clin North Am 1999;34: 799-845 .[Medline] [Order article via Infotrieve]
  • Lewis R., Whiting P., ter Riet G., O'Meara S., Glanville J. A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention . Health Technol Assess 2001;5: 1-131 .[Medline] [Order article via Infotrieve]
  • Fisher A., Brady B. Vacuum assisted wound closure therapy . Issues Emerg Health Technol 2003; 1-6 .

The International Journal of Lower Extremity Wounds, Vol. 6, No. 4, 284-290 (2007)
DOI: 10.1177/1534734607308315
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